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KMID : 0616120120430040297
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 4 p.297 ~ p.301
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Free Radical Scavengers of Taxillus delavayi (Van Tiegh.) Danser.
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Lee Chung-Hak
Ahn Dal-Rae
Cui Xun
Yang Jae-Heon
Lee Eun-Byeol
Xing Ming Ming
Tao Chao
Shin Tae-Yong
Cho Chong-Hyeon
Lee Jae-Hyeok
Park Jeong-Suk
Kim Dae-Keun
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Abstract
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In the course of screening for antioxidant compounds by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH), a total extract of the twigs of Taxillus delavayi (Loranthaceae) was found to show potent radical scavenging activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of two phenolic compounds, catechin (1) and galloyl catechin (2), as active principles. Their structures were elucidated by spectroscopic studies. These two compounds showed the significant antioxidative effects on DPPH, and riboflavin- and xanthin-originated superoxide quenching activities. And these two compounds also showed strong nitric oxide radical scavenging effects. In riboflavin- and xanthin-originated superoxide quenching activities and nitric oxide radical scavenging effect, compound 2 showed better antioxidant activities than vitamin C.
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KEYWORD
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Taxillus delavayi , Loranthaceae , DPPH , Superoxide quenching activity , Radical scavenging effect
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